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Overdose signs and symptoms might include migraine, drowsiness, vision modifications, sluggish heart price, chest pain or heavy feeling, pain spreading out to the arm or shoulder, nausea or vomiting, sweating, seizure (convulsions), shallow breathing, or breathing that quits.

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Short-term reduction of preliminary dosage could be needed in rheumatoid arthritis clients with problematic side impacts. Failing this, in adults a preliminary double (filling) dosage of 800 milligrams (=620 milligrams base), or in kids 10 mg base/kg could be taken in two divided dosages, 6 hours apart.

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